FridayScience today features a promising oncology therapy: “CAR-T cells have potent effects to clear residual tumor after incomplete resection in a variety of preclinical models”
Researchers from University of Pennsylvania described how they added chimeric antigen receptor T cells to a gel (fibrin sealant) designed to prevent bleeding after surgery. After adding the gel to the surgical wounds of 20 mice right after they had hard-to-treat tumors resected, it prevented recurrence in 19 of them without interfering with healing.
This study confirmed findings of another study of University of North Carolina on mice with glioblastoma where similar results were observed. Now, the therapy is on its way to being tested in humans.
Interested in reading more? A CAR-T cell gel kills residual cancer cells left over from surgery
UOP Study: Science – Chimeric antigen receptor T cells as adjuvant therapy for unresectable adenocarcinoma
